A New Strategy for Enzyme Discovery in Microbiomes

Our recent Science paper reports the development of chemically guided functional profiling and the discovery of a new glycyl radical enzyme in human gut microbes that metabolizes a host-derived amino acid. Congratulations to Ben, Yolanda, Spencer, Ana, and Jonathan, and thank you to our wonderful collaborators Yifeng Wei (MIT), Eric Franzosa, and Curtis Huttenhower (Harvard School of Public Health, Broad Institute)!