Publications by Year (2019)

Publications | 2019

2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 |2012 | Pre-2011

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66 - Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

66. Chen, Sifan; Henderson, Ayana; Petriello, Michael C.; Romano, Kymberleigh A.; Gearing, Mary; Miao, Ji; Schell, Mareike; Sandoval-Espinola, Walter J.; Tao, Jiahui; Sha, Bingdong; Graham, Mark; Crooke, Rosanne; Kleinridders, Andre; Balskus, Emily P.; Rey, Federico E.; Morris, Andrew J.; Biddinger, Sudha B. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019, 30, 1141–1151.e5. DOI: https://doi.org/10.1016/j.cmet.2019.08.021.

65 - The mysteries of macrocyclic colibactins

65. Carlson, Erik S.; Balskus, Emily P. The Mysteries of Macrocyclic Colibactins. Nat. Chem. 2019, 11, 867–869. DOI: https://doi.org/10.1038/s41557-019-0339-1.

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64 - Reactivity of an Unusual Amidase May Explain Colibactin’s DNA Cross-Linking Activity

64. Jiang, Yindi; Stornetta, Alessia; Villalta, Peter W.; Wilson, Matthew R.; Boudreau, Paul D.; Zha, Li; Balbo, Silvia; Balskus, Emily P. Reactivity of an Unusual Amidase May Explain Colibactin’s DNA Cross-Linking Activity. J. Am. Chem. Soc. 2019, 141, 11489–11496. DOI: https://doi.org/10.1021/jacs.9b02453.
Preprint: bioRxiv 2019. DOI: https://doi.org/10.1101/567248.

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63 - Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

63. Maini Rekdal, Vayu; Bess, Elizabeth N.; Bisanz, Jordan E.; Turnbaugh, Peter J.; Balskus, Emily P. Discovery and Inhibition of an Interspecies Gut Bacterial Pathway for Levodopa Metabolism. Science 2019, 364, eaau6323. DOI: https://doi.org/10.1126/science.aau6323.

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62 - Enzymes that detoxify marine toxins

62. McCallum, Monica E.; Balskus, Emily P. Enzymes That Detoxify Marine Toxins. Nature 2019, 570, 315–316. DOI: https://doi.org/10.1038/d41586-019-01742-1.

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61 - In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Design of a Fluorogenic Activity Probe

61. Volpe, Matthew R.; Wilson, Matthew R.; Brotherton, Carolyn A.; Winter, Ethan S.; Johnson, Sheila E.; Balskus, Emily P. In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe. ACS Chem. Biol. 2019, 14, 1097–1101. DOI: https://doi.org/10.1021/acschembio.9b00069.

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60 - The human gut bacterial genotoxin colibactin alkylates DNA

60. Wilson, Matthew R.; Jiang, Yindi; Villalta, Peter W.; Stornetta, Alessia; Boudreau, Paul D.; Carrá, Andrea; Brennan, Caitlin A.; Chun, Eunyoung; Ngo, Lizzie; Samson, Leona D.; Engelward, Bevin P.; Garrett, Wendy S.; Balbo, Silvia; Balskus, Emily P. The Human Gut Bacterial Genotoxin Colibactin Alkylates DNA. Science 2019, 363, eaar7785. DOI: https://doi.org/10.1126/science.aar7785.

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59 - An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

59. Ng, Tai L.; Rohac, Roman; Mitchell, Andrew J.; Boal, Amie K.; Balskus, Emily P. An N-Nitrosating Metalloenzyme Constructs the Pharmacophore of Streptozotocin. Nature 2019, 566, 94–99. DOI: https://doi.org/10.1038/s41586-019-0894-z.

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58 - A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia

58. Peck, Spencer C.; Denger, Karin; Burrichter, Anna; Irwin, Stephania M.; Balskus, Emily P.; Schleheck, David. A Glycyl Radical Enzyme Enables Hydrogen Sulfide Production by the Human Intestinal Bacterium Bilophila wadsworthia. Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 3171–3176. DOI: https://doi.org/10.1073/pnas.1815661116.

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57 - Biocatalytic Friedel–Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme

57. Schultz, Erica E.; Braffman, Nathaniel R.; Luescher, Michael U.; Hager, Harry H.; Balskus, Emily P. Biocatalytic Friedel–Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme. Angew. Chem., Int. Ed. 2019, 58, 3151–3155. DOI: https://doi.org/10.1002/anie.201814016.

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56 - Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

56. Martins, Teresa P.; Rouger, Caroline; Glasser, Nathaniel R.; Freitas, Sara; de Fraissinette, Nelly B.; Balskus, Emily P.; Tasdemir, Deniz; Leão, Pedro N. Chemistry, Bioactivity and Biosynthesis of Cyanobacterial Alkylresorcinols. Nat. Prod. Rep. 2019, 36, 1437–1461. DOI: https://doi.org/10.1039/c8np00080h.

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55 - Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria

55. Orman, Marina; Bodea, Smaranda; Funk, Michael A.; Campo, Ana Martínez-del; Bollenbach, Maud; Drennan, Catherine L.; Balskus, Emily P. Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. J. Am. Chem. Soc. 2019, 141, 33–37. DOI: https://doi.org/10.1021/jacs.8b04883.

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54 - Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline

54. Chittim, Carina L.; Martínez del Campo, Ana; Balskus, Emily P. Gut Bacterial Phospholipase Ds Support Disease-Associated Metabolism by Generating Choline. Nat. Microbiol. 2019, 4, 155–163. DOI: https://doi.org/10.1038/s41564-018-0294-4.

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