112 - Thoughts for the future

112. Alkhalaf, Lona M.; Arrowsmith, Cheryl; Balskus, Emily P.; Bergamini, Giovanna; Bhandari, Rashna; Chang, Christopher J.; Chen, Peng; Chen, Xing; Ciulli, Alessio; Cricco, Julia A.; Davis, Benjamin G.; Delbianco, Martina; Dudareva, Natalia; Dueber, Erin; Ferguson, Fleur; de Giuseppe, Priscila Oliveira; Hamachi, Itaru; Hammond, Ming Chen; Hatzios, Stavroula K.; Do Heo, Won; Janet, Jon Paul; Kamat, Siddhesh S.; Knapp, Stefan; Krishnan, Yamuna; Lang, Kathrin; Laraia, Luca; Leveson-Gower, Reuben B.; Li, Xiang David; Liu, David R.; Liu, Mo-Fang; London, Nir; Mahanta, Nilkamal; Mayor-Ruiz, Cristina; Muir, Tom; Murakami, Mário Tyago; Rhee, Hyun-Woo; Robers, Matt; Satz, Alex; Schulman, Brenda A.; Shen, Ben; Shoichet, Brian; Strauss, Erick; Suzuki, Tsutomu; Tiwary, Pratyush; Waldmann, Herbert; Ward, Thomas R.; Weeks, Amy; Weerapana, Eranthie; Winter, Georg. Thoughts for the Future. Nat. Chem. Biol. 2025, 21, 6–15. DOI: https://doi.org/10.1038/s41589-024-01802-2.

111 - Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme

111. Bae, Minwoo; Le, Chi; Mehta, Raaj S.; Dong, Xueyang; Pieper, Lindsey M.; Ramirez, Lorenzo; Alexander, Margaret; Kiamehr, Sina; Turnbaugh, Peter J.; Huttenhower, Curtis; Chan, Andrew T.; Balskus, Emily P. Metatranscriptomics-Guided Discovery and Characterization of a Polyphenol-Metabolizing Gut Microbial Enzyme. Cell Host Microbe 2024, 32, 1887–1896.e8. DOI: https://doi.org/10.1016/j.chom.2024.10.002.

110 - Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature’s Known Radical Chemistry

110. Fu, Beverly; Yang, Hao; Kountz, Duncan J.; Lundahl, Maike N.; Beller, Harry R.; Broderick, William E.; Broderick, Joan B.; Hoffman, Brian H.; Balskus, Emily P. Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature’s Known Radical Chemistry. J. Am. Chem. Soc. 2024, 146, 29645–29655. DOI: https://doi.org/10.1021/jacs.4c10348.

109 - Prevotella are major contributors of sialidases in the human vaginal microbiome

109. Pelayo, Paula; Hussain, Fatima A.; Werlang, Caroline A.; Wu, Chloe M.; Woolston, Benjamin M.; Xiang, Claire M.; Rutt, Lindsay; France, Michael T.; Ravel, Jacques; Ribbeck, Katharina; Kwon, Douglas S.; Balskus, Emily P. Prevotella Are Major Contributors of Sialidases in the Human Vaginal Microbiome. Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2400341121. DOI: https://doi.org/10.1073/pnas.2400341121.
Preprint: bioRxiv 2024. DOI: https://doi.org/10.1101/2024.01.09.574895.

108 - Prevotella timonensis degrades the vaginal epithelial glycocalyx through high fucosidase and sialidase activities

108. Segui-Perez, Celia; de Jongh, Rivka; Jonkergouw, Robin L. W.; Pelayo, Paula; Balskus, Emily P.; Zomer, Aldert; Strijbis, Karin. Prevotella timonensis Degrades the Vaginal Epithelial Glycocalyx through High Fucosidase and Sialidase Activities. mBio 2024, 15, e0069124. DOI: https://doi.org/10.1128/mbio.00691-24.

107 - Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

107. Mandarino Alves, Amanda; Lecchi, Chiara; Lopez, Sharon; Stornetta, Alessia; Mathai, Prince P.; Villalta, Peter W.; Ishii, Satoshi; Balskus, Emily P.; Balbo, Silvia; Khoruts, Alexander. Dysfunctional Mucus Structure in Cystic Fibrosis Increases Vulnerability to Colibactin-Mediated DNA Adducts in the Colon Mucosa. Gut Microbes 2024, 16, 2387877. DOI: https://doi.org/10.1080/19490976.2024.2387877.

106 - A metabolomics pipeline highlights microbial metabolism in bloodstream infections

106. Mayers, Jared R.; Varon, Jack; Zhou, Ruixuan R.; Daniel-Ivad, Martin; Beaulieu, Courtney; Bhosle, Amrisha; Glasser, Nathaniel R.; Lichtenauer, Franziska M.; Ng, Julie; Vera, Mayra Pinilla; Huttenhower, Curtis; Perrella, Mark A.; Clish, Clary B.; Zhao, Sihai D.; Baron, Rebecca M.; Balskus, Emily P. A Metabolomics Pipeline Highlights Microbial Metabolism in Bloodstream Infections. Cell 2024, 187, 4095–4112.e21. DOI: https://doi.org/10.1016/j.cell.2024.05.035.
Preprint: bioRxiv 2023. DOI: https://doi.org/10.1101/2023.09.21.558834.

105 - Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas

105. McCurry, Megan D.; D’Agostino, Gabriel D.; Walsh, Jasmine T.; Bisanz, Jordan E.; Zalosnik, Ines; Dong, Xueyang; Morris, David J.; Korzenik, Joshua R.; Edlow, Andrea G.; Balskus, Emily P.; Turnbaugh, Peter J.; Huh, Jun R.; Devlin, A. Sloan. Gut Bacteria Convert Glucocorticoids into Progestins in the Presence of Hydrogen Gas. Cell 2024, 187, 2952–2968.e13. DOI: https://doi.org/10.1016/j.cell.2024.05.005.

103 - Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production

103. Bao, Bin; Wang, Youyuan; Boudreau, Pavl; Song, Xinyang; Wu, Meng; Chen, Xi; Patik, Izabel; Tang, Ying; Ouahed, Jodie; Ringel, Amit; Barends, Jared; Wu, Chuan; Balskus, Emily P.; Thiagarajah, Jay; Liu, Jian; Wessels, Michael R.; Lencer, Wayne Isaac; Kasper, Dennis L.; An, Dingding; Horwitz, Bruce Harold; Snapper, Scott B. Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-Derived IL-22 Production. Cell. Mol. Gastroenterol. Hepatol. 2024, 18, 101350. DOI: https://doi.org/10.1016/j.jcmgh.2024.04.007.
Preprint: bioRxiv 2023. DOI: https://doi.org/10.1101/2023.09.05.555400.

102 - Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

102. Li, Chenhao; Stražar, Martin; Mohamed, Ahmed M. T.; Pacheco, Julian A.; Walker, Rebecca L.; Lebar, Tina; Zhao, Shijie; Lockart, Julia; Dame, Andrea; Thurimella, Kumar; Jeanfavre, Sarah; Brown, Eric M.; Ang, Qi Yan; Berdy, Brittany; Sergio, Dallis; Invernizzi, Rachele; Tinoco, Antonio; Pishchany, Gleb; Vasan, Ramachandran S.; Balskus, Emily P.; Huttenhower, Curtis; Vlamakis, Hera; Clish, Clary; Shaw, Stanley Y.; Plichta, Damian R.; Xavier, Ramnik J. Gut Microbiome and Metabolome Profiling in Framingham Heart Study Reveals Cholesterol-Metabolizing Bacteria. Cell 2024, 187, 1834–1852.e19. DOI: https://doi.org/10.1016/j.cell.2024.03.014.