114 - Thoughts for the future

114. Alkhalaf, Lona M.; Arrowsmith, Cheryl; Balskus, Emily P.; Bergamini, Giovanna; Bhandari, Rashna; Chang, Christopher J.; Chen, Peng; Chen, Xing; Ciulli, Alessio; Cricco, Julia A.; Davis, Benjamin G.; Delbianco, Martina; Dudareva, Natalia; Dueber, Erin; Ferguson, Fleur; de Giuseppe, Priscila Oliveira; Hamachi, Itaru; Hammond, Ming Chen; Hatzios, Stavroula K.; Do Heo, Won; Janet, Jon Paul; Kamat, Siddhesh S.; Knapp, Stefan; Krishnan, Yamuna; Lang, Kathrin; Laraia, Luca; Leveson-Gower, Reuben B.; Li, Xiang David; Liu, David R.; Liu, Mo-Fang; London, Nir; Mahanta, Nilkamal; Mayor-Ruiz, Cristina; Muir, Tom; Murakami, Mário Tyago; Rhee, Hyun-Woo; Robers, Matt; Satz, Alex; Schulman, Brenda A.; Shen, Ben; Shoichet, Brian; Strauss, Erick; Suzuki, Tsutomu; Tiwary, Pratyush; Waldmann, Herbert; Ward, Thomas R.; Weeks, Amy; Weerapana, Eranthie; Winter, Georg. Thoughts for the future. Nature Chemical Biology 2025, 21 (1), 6-15. DOI: 10.1038/s41589-024-01802-2.

113 - Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme

113. Bae, Minwoo; Le, Chi; Mehta, Raaj S.; Dong, Xueyang; Pieper, Lindsey M.; Ramirez, Lorenzo; Alexander, Margaret; Kiamehr, Sina; Turnbaugh, Peter J.; Huttenhower, Curtis; Chan, Andrew T.; Balskus, Emily P. Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme. Cell Host & Microbe 2024, 32 (11), 1887-1896.e1888. DOI: https://doi.org/10.1016/j.chom.2024.10.002.

112 - Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

112. Woo, Amelia Y. M.; Sandoval–Espinola, Walter J.; Bollenbach, Maud; Wong, Alison; Sakanaka–Yokoyama, Mariko; Zhang, Qijun; Nieto, Vincent; Rey, Federico E.; Balskus, Emily P. Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism. bioRxiv 2024, 2024.2011.2008.621386. DOI: 10.1101/2024.11.08.621386.

111 - Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature’s Known Radical Chemistry

111. Fu, Beverly; Yang, Hao; Kountz, Duncan J.; Lundahl, Maike N.; Beller, Harry R.; Broderick, William E.; Broderick, Joan B.; Hoffman, Brian H.; Balskus, Emily P. Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature’s Known Radical Chemistry. Journal of the American Chemical Society 2024, 146 (43), 29645-29655. DOI: 10.1021/jacs.4c10348.

110 - Prevotella are major contributors of sialidases in the human vaginal microbiome

110. Pelayo, Paula; Hussain, Fatima A.; Werlang, Caroline A.; Wu, Chloe M.; Woolston, Benjamin M.; Xiang, Claire M.; Rutt, Lindsay; France, Michael T.; Ravel, Jacques; Ribbeck, Katharina; Kwon, Douglas S.; Balskus, Emily P. Prevotella are major contributors of sialidases in the human vaginal microbiome. Proceedings of the National Academy of Sciences 2024, 121 (36), e2400341121. DOI: 10.1073/pnas.2400341121 bioRxiv: https://doi.org/10.1101/2024.01.09.574895.

108 - Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

108. Mandarino Alves, Amanda; Lecchi, Chiara; Lopez, Sharon; Stornetta, Alessia; Mathai, Prince P.; Villalta, Peter W.; Ishii, Satoshi; Balskus, Emily P.; Balbo, Silvia; Khoruts, Alexander. Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa. Gut Microbes 2024, 16 (1), 2387877. DOI: 10.1080/19490976.2024.2387877.

107 - A metabolomics pipeline highlights microbial metabolism in bloodstream infections

107. Mayers, Jared R.; Varon, Jack; Zhou, Ruixuan R.; Daniel-Ivad, Martin; Beaulieu, Courtney; Bhosle, Amrisha; Glasser, Nathaniel R.; Lichtenauer, Franziska M.; Ng, Julie; Vera, Mayra Pinilla; Huttenhower, Curtis; Perrella, Mark A.; Clish, Clary B.; Zhao, Sihai D.; Baron, Rebecca M.; Balskus, Emily P. A metabolomics pipeline highlights microbial metabolism in bloodstream infections. Cell 2024, 187 (15), 4095-4112.e4021. DOI: https://doi.org/10.1016/j.cell.2024.05.035.

106 - Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas

106. McCurry, Megan D.; D’Agostino, Gabriel D.; Walsh, Jasmine T.; Bisanz, Jordan E.; Zalosnik, Ines; Dong, Xueyang; Morris, David J.; Korzenik, Joshua R.; Edlow, Andrea G.; Balskus, Emily P.; Turnbaugh, Peter J.; Huh, Jun R.; Devlin, A. Sloan. Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas. Cell 2024, 187 (12), 2952-2968.e2913. DOI: https://doi.org/10.1016/j.cell.2024.05.005.

104 - Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production

104. Bao, Bin; Wang, Youyuan; Boudreau, Pavl; Song, Xinyang; Wu, Meng; Chen, Xi; Patik, Izabel; Tang, Ying; Ouahed, Jodie; Ringel, Amit; Barends, Jared; Wu, Chuan; Balskus, Emily; Thiagarajah, Jay; Liu, Jian; Wessels, Michael R.; Lencer, Wayne Isaac; Kasper, Dennis L.; An, Dingding; Horwitz, Bruce Harold; Snapper, Scott B. Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cellular and Molecular Gastroenterology and Hepatology 2024, 18 (2), 101350. DOI: https://doi.org/10.1016/j.jcmgh.2024.04.007. bioRxiv: https://www.biorxiv.org/content/10.1101/2023.09.05.555400v1.

103 - Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

103. Li, Chenhao; Stražar, Martin; Mohamed, Ahmed M. T.; Pacheco, Julian A.; Walker, Rebecca L.; Lebar, Tina; Zhao, Shijie; Lockart, Julia; Dame, Andrea; Thurimella, Kumar; Jeanfavre, Sarah; Brown, Eric M.; Ang, Qi Yan; Berdy, Brittany; Sergio, Dallis; Invernizzi, Rachele; Tinoco, Antonio; Pishchany, Gleb; Vasan, Ramachandran S.; Balskus, Emily; Huttenhower, Curtis; Vlamakis, Hera; Clish, Clary; Shaw, Stanley Y.; Plichta, Damian R.; Xavier, Ramnik J. Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria. Cell 2024, 187 (8), 1834-1852.e1819. DOI: https://doi.org/10.1016/j.cell.2024.03.014.