75 - Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF

75. McBride, Molly J.; Pope, Sarah R.; Hu, Kai; Okafor, C. Denise; Balskus, Emily P.; Bollinger, J. Martin; Boal, Amie K. Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF. Proceedings of the National Academy of Sciences 2021, 118 (4), e2015931118. DOI: https://doi.org/10.1073/pnas.2015931118.


74 - Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level

74. Kenny, Douglas J.; Plichta, Damian R.; Shungin, Dmitry; Koppel, Nitzan; Hall, A. Brantley; Fu, Beverly; Vasan, Ramachandran S.; Shaw, Stanley Y.; Vlamakis, Hera; Balskus, Emily P.; Xavier, Ramnik J. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level. Cell Host & Microbe 2020, 28 (2), 245-257.e246. DOI: https://doi.org/10.1016/j.chom.2020.05.013.


73 - A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria

73. Bisanz, Jordan E.; Soto-Perez, Paola; Noecker, Cecilia; Aksenov, Alexander A.; Lam, Kathy N.; Kenney, Grace E.; Bess, Elizabeth N.; Haiser, Henry J.; Kyaw, Than S.; Yu, Feiqiao B.; Rekdal, Vayu M.; Ha, Connie W. Y.; Devkota, Suzanne; Balskus, Emily P.; Dorrestein, Pieter C.; Allen-Vercoe, Emma; Turnbaugh, Peter J. A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria. Cell Host & Microbe 2020, 27 (6), 1001-1013.e1009. DOI: https://doi.org/10.1016/j.chom.2020.04.006.


72 - A Peroxodiiron(III/III) Intermediate Mediating Both N-Hydroxylation Steps in Biosynthesis of the N-Nitrosourea Pharmacophore of Streptozotocin by the Multi-domain Metalloenzyme SznF

72. McBride, Molly J.; Sil, Debangsu; Ng, Tai L.; Crooke, Anne Marie; Kenney, Grace E.; Tysoe, Christina R.; Zhang, Bo; Balskus, Emily P.; Boal, Amie K.; Krebs, Carsten; Bollinger, J. Martin, Jr. A Peroxodiiron(III/III) Intermediate Mediating Both N-Hydroxylation Steps in Biosynthesis of the N-Nitrosourea Pharmacophore of Streptozotocin by the Multi-domain Metalloenzyme SznF. Journal of the American Chemical Society 2020, 142 (27), 11818-11828. DOI: https://doi.org/10.1021/jacs.0c03431.


68 -Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

68. Backman, Lindsey R. F.; Huang, Yolanda Y.; Andorfer, Mary C.; Gold, Brian; Raines, Ronald T.; Balskus, Emily P.; Drennan, Catherine L. Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme. eLife 2020, 9, e51420. DOI: https://doi.org/10.7554/eLife.51420.


67 - A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

67. Maini Rekdal, Vayu; Nol Bernadino, Paola; Luescher, Michael U.; Kiamehr, Sina; Le, Chip; Bisanz, Jordan E.; Turnbaugh, Peter J.; Bess, Elizabeth N.; Balskus, Emily P. A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols. eLife 2020, 9, e50845. DOI:https://doi.org/10.7554/eLife.50845 bioRxiv: https://doi.org/10.1101/725358.