91 - Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators

91. Dong, Xueyang; Guthrie, Ben G. H.; Alexander, Margaret; Noecker, Cecilia; Ramirez, Lorenzo; Glasser, Nathaniel R.; Turnbaugh, Peter J.; Balskus, Emily P. Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators. Nature Communications 2022, 13 (1), 7624. DOI: 10.1038/s41467-022-33576-3.

90 - A small molecule inhibitor prevents gut bacterial genotoxin production

90. Volpe, Matthew R.; Velilla, José A.; Daniel-Ivad, Martin; Yao, Jenny J.; Stornetta, Alessia; Villalta, Peter W.; Huang, Hsin-Che; Bachovchin, Daniel A.; Balbo, Silvia; Gaudet, Rachelle; Balskus, Emily P. A small molecule inhibitor prevents gut bacterial genotoxin production. Nature Chemical Biology 2023, 19 (2), 159-167. DOI: 10.1038/s41589-022-01147-8.

87 - Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer

87. Fu, Beverly; Nazemi, Azadeh; Levin, Benjamin J.; Yang, Zhongyue; Kulik, Heather J.; Balskus, Emily P. Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer. Journal of the American Chemical Society 2022, 144 (25), 11110-11119. DOI: https://doi.org/10.1021/jacs.1c13580.

85 - The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

85. Reed, Amber D.; Fletcher, Joshua R.; Huang, Yun-Yi Y.; Thanissery, Rachael; Rivera, Andrew J.; Parsons, Robert J.; Stewart, Anne K.; Kountz, D. J.; Shen, Aimee; Balskus, Emily P.; Theriot, Casey M. The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia. mSphere 2022, 7 (2), e00926-00921. DOI: https://doi.org/10.1128/msphere.00926-21. bioRxiv: https://www.biorxiv.org/content/10.1101/2021.11.12.468462v1

84 - Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

84. Bloom, Seth M.; Mafunda, Nomfuneko A.; Woolston, Benjamin M.; Hayward, Matthew R.; Frempong, Josephine F.; Abai, Aaron B.; Xu, Jiawu; Mitchell, Alissa J.; Westergaard, Xavier; Hussain, Fatima A.; Xulu, Nondumiso; Dong, Mary; Dong, Krista L.; Gumbi, Thandeka; Ceasar, F. Xolisile; Rice, Justin K.; Choksi, Namit; Ismail, Nasreen; Ndung’u, Thumbi; Ghebremichael, Musie S.; Relman, David A.; Balskus, Emily P.; Mitchell, Caroline M.; Kwon, Douglas S. Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation. Nature Microbiology 2022, 7 (3), 434-450. DOI: https://doi.org/10.1038/s41564-022-01070-7. bioRxiv: https://www.biorxiv.org/content/10.1101/2021.06.12.448098v1.

83 - Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

83. Braffman, Nathaniel R.; Ruskoski, Terry B.; Davis, Katherine M.; Glasser, Nathaniel R.; Johnson, Cassidy; Okafor, C. Denise; Boal, Amie K.; Balskus, Emily P. Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis. eLife 2022, 11, e75761. DOI: https://doi.org/10.7554/eLife.75761. bioRxiv: https://www.biorxiv.org/content/10.1101/2021.12.02.470901v1