Publications by Year (2022)

Publications | 2022

2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 |2012 | Pre-2011

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92 - Elucidating the Chemistry and Biology of the Human Microbiome

92. Balskus, Emily P. Elucidating the Chemistry and Biology of the Human Microbiome. Biochemistry 2022, 61, 2777–2778. DOI: https://doi.org/10.1021/acs.biochem.2c00652.

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91 - Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators

91. Dong, Xueyang; Guthrie, Ben G. H.; Alexander, Margaret; Noecker, Cecilia; Ramirez, Lorenzo; Glasser, Nathaniel R.; Turnbaugh, Peter J.; Balskus, Emily P. Genetic Manipulation of the Human Gut Bacterium Eggerthella lenta Reveals a Widespread Family of Transcriptional Regulators. Nat. Commun. 2022, 13, 7624. DOI: https://doi.org/10.1038/s41467-022-33576-3.

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90 - A small molecule inhibitor prevents gut bacterial genotoxin production

90. Volpe, Matthew R.; Velilla, José A.; Daniel-Ivad, Martin; Yao, Jenny J.; Stornetta, Alessia; Villalta, Peter W.; Huang, Hsin-Che; Bachovchin, Daniel A.; Balbo, Silvia; Gaudet, Rachelle; Balskus, Emily P. A Small Molecule Inhibitor Prevents Gut Bacterial Genotoxin Production. Nat. Chem. Biol. 2023, 19, 159–167. DOI: https://doi.org/10.1038/s41589-022-01147-8.

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89 - Structural basis of colibactin activation by the ClbP peptidase

89. Velilla, José A.; Volpe, Matthew R.; Kenney, Grace E.; Walsh, Richard M.; Balskus, Emily P.; Gaudet, Rachelle. Structural Basis of Colibactin Activation by the ClbP Peptidase. Nat. Chem. Biol. 2023, 19, 151–158. DOI: https://doi.org/10.1038/s41589-022-01142-z.

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88 - Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A

88. Martins, Teresa P.; Glasser, Nathaniel R.; Kountz, Duncan J.; Oliveira, Paulo; Balskus, Emily P.; Leão, Pedro N. Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A. ACS Chem. Biol. 2022, 17, 2528–2537. DOI: https://doi.org/10.1021/acschembio.2c00464.
Preprint: ChemRxiv 2022. DOI: https://doi.org/10.26434/chemrxiv-2022-jv5n7.

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87 - Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer

87. Fu, Beverly; Nazemi, Azadeh; Levin, Benjamin J.; Yang, Zhongyue; Kulik, Heather J.; Balskus, Emily P. Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer. J. Am. Chem. Soc. 2022, 144, 11110–11119. DOI: https://doi.org/10.1021/jacs.1c13580.

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86 - Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily

86. Le, Chi; Bae, Minwoo; Kiamehr, Sina; Balskus, Emily P. Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily. Annu. Rev. Biochem. 2022, 91, 475–504. DOI: https://doi.org/10.1146/annurev-biochem-032620-110804.

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85 - The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

85. Reed, Amber D.; Fletcher, Joshua R.; Huang, Yun-Yi Y.; Thanissery, Rachael; Rivera, Andrew J.; Parsons, Robert J.; Stewart, Anne K.; Kountz, Duncan J.; Shen, Aimee; Balskus, Emily P.; Theriot, Casey M. The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia. mSphere 2022, 7, e00926-21. DOI: https://doi.org/10.1128/msphere.00926-21.
Preprint: bioRxiv 2021. DOI: https://doi.org/10.1101/2021.11.12.468462.

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84 - Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

84. Bloom, Seth M.; Mafunda, Nomfuneko A.; Woolston, Benjamin M.; Hayward, Matthew R.; Frempong, Josephine F.; Abai, Aaron B.; Xu, Jiawu; Mitchell, Alissa J.; Westergaard, Xavier; Hussain, Fatima A.; Xulu, Nondumiso; Dong, Mary; Dong, Krista L.; Gumbi, Thandeka; Ceasar, F. Xolisile; Rice, Justin K.; Choksi, Namit; Ismail, Nasreen; Ndung’u, Thumbi; Ghebremichael, Musie S.; Relman, David A.; Balskus, Emily P.; Mitchell, Caroline M.; Kwon, Douglas S. Cysteine Dependence of Lactobacillus iners Is a Potential Therapeutic Target for Vaginal Microbiota Modulation. Nat. Microbiol. 2022, 7, 434–450. DOI: https://doi.org/10.1038/s41564-022-01070-7.
Preprint: bioRxiv 2021. DOI: https://doi.org/10.1101/2021.06.12.448098.

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83 - Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

83. Braffman, Nathaniel R.; Ruskoski, Terry B.; Davis, Katherine M.; Glasser, Nathaniel R.; Johnson, Cassidy; Okafor, C. Denise; Boal, Amie K.; Balskus, Emily P. Structural Basis for an Unprecedented Enzymatic Alkylation in Cylindrocyclophane Biosynthesis. eLife 2022, 11, e75761. DOI: https://doi.org/10.7554/eLife.75761.
Preprint: bioRxiv 2021. DOI: https://doi.org/10.1101/2021.12.02.470901.

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82 - The bacterial toxin colibactin triggers prophage induction

82. Silpe, Justin E.; Wong, Joel W. H.; Owen, Siân V.; Baym, Michael; Balskus, Emily P. The Bacterial Toxin Colibactin Triggers Prophage Induction. Nature 2022, 603, 315–320. DOI: https://doi.org/10.1038/s41586-022-04444-3.
Preprint: bioRxiv 2021. DOI: https://doi.org/10.1101/2021.05.24.445430.

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