127. Colibactin produced by a honeybee symbiont defends against pathogens and shapes the gut community. (Copy)

127. Song, Yulin; Powell, J. Elijah; Wong, Joel W. H.; Liu, Yunxi; Aguilar Ramos, Miguel A.; De Jong, Tyler; Lariviere, Patrick J.; Maganti, Jayaditya; Balskus, Emily P.; Moran, Nancy A. Colibactin produced by a honeybee symbiont defends against pathogens and shapes the gut community. bioRxiv 2025, 2025.2012.2027.695564. DOI: https://doi.org/10.64898/2025.12.27.695564.

126 - The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin

126. Carlson, Erik S.; Haslecker, Raphael; Lecchi, Chiara; Aguilar Ramos, Miguel A.; Vennelakanti, Vyshnavi; Honaker, Linda; Stornetta, Alessia; Millán, Estela S.; Johnson, Bruce A.; Kulik, Heather J.; Balbo, Silvia; Villalta, Peter W.; D’Souza, Victoria M.; Balskus, Emily P. The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin. Science 2025, 390 (6777), eady3571. DOI: https://www.science.org/doi/10.1126/science.ady3571

125 - The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links

125. Altshuller, Maria; He, Xu; MacKrell, Elliot J.; Wernke, Kevin M.; Airan, Yougant; Wong, Joel W. H.; Sellés-Baiget, Selene; Wang, Ting-Yu; Chou, Tsui-Fen; Duxin, Julien P.; Balskus, Emily P.; Herzon, Seth B.; Semlow, Daniel R. The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links. Nature Communications 2025, 16 (1), 10563. DOI: 10.1038/s41467-025-65606-1.

124 - Systematic identification and characterization of regulators of aryl hydrocarbon receptor signaling

124. Verma, Manasvi; Desai, Kushaal; Ding, Yufang; Wang, Xingren; Bae, Minwoo; Rakoff-Nahoum, Seth; Balskus, Emily P.; Fischbach, Michael A.; Jost, Marco. Systematic identification and characterization of regulators of aryl hydrocarbon receptor signaling. bioRxiv 2025, 2025.2009.2015.676391. DOI:10.1101/2025.09.15.676391.

123 - A genotoxin associated with colorectal cancer linked to gut dysbiosis in children with cystic fibrosis

123. Barrack, Kaitlyn E.; Surve, Sarvesh V.; de Sousa Bezerra, Ana V.; Murphy, Caitlin E.; Soucy, Shannon M.; Aguilar Ramos, Miguel A.; Valls, Rebecca A.; Ruff, Rebekah D.; Balskus, Emily P.; Sanville, Julie L.; Madan, Juliette C.; O’Toole, George A. A genotoxin associated with colorectal cancer linked to gut dysbiosis in children with cystic fibrosis. bioRxiv 2025, 2025.2009.2004.674286. DOI: 10.1101/2025.09.04.674286.

122 - Characterizing and engineering post-translational modifications with high-throughput cell-free expression

122. Wong, Derek A.; Shaver, Zachary M.; Cabezas, Maria D.; Daniel-Ivad, Martin; Warfel, Katherine F.; Prasanna, Deepali V.; Sobol, Sarah E.; Fernandez, Regina; Tobias, Fernando; Filip, Szymon K.; Hulbert, Sophia W.; Faull, Peter; Nicol, Robert; DeLisa, Matthew P.; Balskus, Emily P.; Karim, Ashty S.; Jewett, Michael C. Characterizing and engineering post-translational modifications with high-throughput cell-free expression. Nature Communications 2025, 16 (1), 7215. DOI: 10.1038/s41467-025-60526-6. bioRxiv: https://doi.org/10.1101/2024.03.25.586624.

116 - A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury

116. Richards-Corke, Khyle C.; Jiang, Yindi; Yeliseyev, Vladimir; Zhang, Yancong; Franzosa, Eric A.; Wang, Zhipeng A.; Yapa Abeywardana, Maheeshi; Cole, Phillip A.; Huttenhower, Curtis; Bry, Lynn; Balskus, Emily P. A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury. ACS Chemical Biology 2025, 20 (1), 48-55. DOI: 10.1021/acschembio.3c00556.